Previous research has shown overweight and obesity during adolescence are associated with increased morbidity. In the first study, the authors aimed to estimate the prevalence of overweight and obesity among adolescents in England using routinely collected healthcare data. In the second study, the authors also investigated the association between adolescent body mass index (BMI) and the onset of co-morbid conditions during adolescence.
The studies were led by Dr Dinesh Giri, Honorary Senior Lecturer at Bristol Medical School at the University of Bristol and Consultant Paediatric Endocrinologist from Bristol Royal Hospital for Children, and Dr Senthil Senniappan, Consultant Paediatric Endocrinologist at Alder Hey Children’s Hospital.
The researchers used linked primary (Clinical Practice Research Datalink [CPRD]) and secondary (Hospital Episode Statistics) care data for their analysis.
Among adolescents aged 12-17 years registered at a CPRD contributing practice (around 20% of practices nationwide contribute) from 2008-2023 with BMI readings and using the UK 1990 growth reference centiles (a widely-used reference for studies of this type). Overweight was defined as at or above the 91st centile and obesity as at or above the 98th centile [1].
Three-year rolling prevalences for overweight and obesity were calculated, since these provide more stable estimates, and a clearer picture of the longer-term trends rather than focusing on small year-to-year changes. The authors explain this helps to smooth out any random ups and downs that might happen in a single year.
Adolescents with a healthy weight BMI, at or above the 2nd and below the 91st centile, were included as a comparator. The sociodemographic and clinical characteristics for adolescents were described at the first BMI recording. The incidence of new comorbidities during adolescence was compared between adolescents living with overweight or obesity and those with healthy weight using statistical modelling.
The period prevalence of overweight and obesity increased from 22% in 2008-2010 to 33% in 2021-2023. There was evidence of a steeper increase during / following the COVID-19 pandemic.
Of the 139,258 adolescents living as overweight, 140,990 adolescents with obesity and 560,789 adolescents with healthy weight, higher proportions with overweight (26%) or obesity (31%) than healthy weight (22%) resided in the most deprived geographies (calculated by decile, or groups of 10%).
Higher proportions of those living with overweight (8%) and obesity (27%) had lived with obesity during childhood than those with healthy weight (1%). New onset of mental health (obesity: 8.6% vs overweight: 7.8% vs healthy weight: 7.1%), physical (11.6% vs 10.7% vs 9.3%) and cardiometabolic (3.1% vs 1.2% vs 0.5%) comorbidities during adolescence was higher in adolescents living with obesity than overweight and lowest in those with healthy weight.
The second study investigated other comorbidities in more detail. Out of the 15 comorbidities investigated, the risks of 14 were significantly higher in adolescents living with overweight or obesity compared to those with healthy weight.
Over a mean follow-up of six years, the risk (Figure 1 of second abstract) of many comorbidities was higher in adolescents living with overweight (n=139,258) or obesity (n=140,990) than those with healthy weight (n=560,789), specifically; obstructive sleep apnoea (3 times higher [overweight] and 8 times higher [obesity]), type 2 diabetes (3 and 11 times higher) and metabolic dysfunction-associated steatotic liver disease (3 and 12 times higher), prediabetes (2 and 4 times higher) and polycystic ovary syndrome (PCOS) (2 and 4 times higher).
The authors concluded:
“The burden of overweight and obesity among adolescents in England is substantial and increased between 2008-2023. There is a significantly higher risk of early onset of many, particularly cardiometabolic, comorbidities among adolescents living with overweight or obesity, with risk increasing as BMI increases.”
They added:
“Over the past 15 years, obesity in adolescents has risen significantly due to a combination of increased consumption of ultra-processed foods, sedentary lifestyles driven by excessive screen time, inadequate sleep, and rising mental health challenges. Additionally, reduced opportunities for physical activity and socioeconomic disparities have further contributed to an environment that promotes unhealthy lifestyles.”
On comorbidities, they said:
“For many weight-related comorbidities, overweight and obesity in adolescence are associated with a higher risk during both adolescence and adulthood. Change of BMI in adolescence may have long-term impact on the risk of developing comorbidities. Increased focus on weight-management in adolescence could lead to long-term improvement in overall health.”
The study was funded by Novo Nordisk.
Read the papers
‘Estimating the prevalence of overweight and obesity and the incidence of comorbidities in adolescents living with overweight and obesity: a cohort study using routinely collected healthcare data in England between 2008 and 2023’ by D Giri et al. presented at the European Congress on Obesity (ECO)
‘Estimating the effect of overweight and obesity during adolescence on the risk of long-term comorbidities: a population-based retrospective analysis in England between 2008 and 2023; by S Senniappan et al. presented at the European Congress on Obesity (ECO)