Kidney disease research

There are many research projects which take place across Bristol.

Current research projects

Reducing inequity in transplantation: The ASK Trial: improving AccesS to Kidney transplantation https://doi.org/10.1186/ISRCTN10989132
Bailey PK, Ben-Shlomo Y, Caskey FJ et al. Development of an intervention to improve access to living-donor kidney transplantation (the ASK study). PLoS One. 2021 Jun 25;16(6):e0253667
Preparing older people for kidney failure treatments: the Prepare for Kidney Care trial https://doi.org/10.1186/ISRCTN17133653 A national trial which aims to help older people with kidney disease make the right decision for them when their kidney function is getting very low.
Comparing different types of dialysis treatment: the H4RT trial https://doi.org/10.1186/ISRCTN10997319 A national trial comparing different types of blood filtering treatments for kidney failure.
Understanding the management of and outcomes following heart attacks in people with kidney disease: Inequities in heart-kidney care: Why are people with kidney disease at increased risk of death and disability after a heart attack?
https://fundingawards.nihr.ac.uk/award/NIHR300906
Understanding treatment preferences of older Patients and their families deciding between dialysis and comprehensive conservative Care for Kidney failure: the UNPACK study
https://fundingawards.nihr.ac.uk/award/DRF-2017-10-127

Research to understand transplant inequity and to identify barriers to kidney donation and transplantation:

Taylor DM, Bradley JA, Bradley C et al. Limited health literacy is associated with reduced access to kidney transplantation. Kidney Int. 2019 May;95(5):1244-1252.
Taylor DM, Fraser SDS, Bradley JA. A Systematic Review of the Prevalence and Associations of Limited Health Literacy in CKD. Clin J Am Soc Nephrol. 2017 Jul 7;12(7):1070-1084.
Bailey PK, Tomson CRV, MacNeill S. A multicenter cohort study of potential living kidney donors provides predictors of living kidney donation and non-donation. Kidney Int. 2017 Nov;92(5):1249-1260.
Bailey PK, Ben-Shlomo Y, Tomson CR, Owen-Smith A. Socioeconomic deprivation and barriers to live-donor kidney transplantation: a qualitative study of deceased-donor kidney transplant recipients. BMJ Open. 2016 Mar 2;6(3):e010605.
Bailey PK, Caskey FJ, MacNeill S, Tomson CRV, Dor FJMF, Ben-Shlomo Y. Mediators of Socioeconomic Inequity in Living-donor Kidney Transplantation: Results From a UK Multicenter Case-Control Study. Transplant Direct. 2020 Mar 13;6(4):e540.
Wong K, Owen-Smith A, Caskey F et al. Investigating Ethnic Disparity in Living-Donor Kidney Transplantation in the UK: Patient-Identified Reasons for Non-Donation among Family Members. J Clin Med. 2020 Nov 21;9(11):3751

Analysis around the prescription of RAS blockers and risk of acute kidney injury:

Scott J, Jones T, Redaniel MT et al. Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin
aldosterone system inhibitors: A population based cohort study using the clinical practice research datalink. BMC Nephrol. 2019;20(1):481.
A systematic review, undertaken by NIHR Applied Research Collaboration West (ARC West), into reducing harm from acute kidney injury and developing an effective sick day rule. ‘Morden A, Horwood J, Whiting P et al.
The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol. Morden, A, Horwood, J, Syst Rev 2015;4:139
The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol. Morden, A, Horwood, J, Syst Rev 2015;4:139
Establishing teleclinics for kidney transplant recipients: Udayaraj U, Watson O, Ben-Shlomo Y et al. Establishing a tele-clinic service for kidney transplant recipients through a patient-codesigned quality improvement project. BMJ Open Qual. 2019 Apr 8;8(2):e000427.
A systematic review and meta-analysis on the question What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? Whiting P, Morden A, Tomlinson LA et al.
What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? A systematic review and meta-analysis. BMJ Open 2017;7(4):e012674

Dr Dominic Taylor, Consultant Nephrologist at North Bristol NHS Trust
Professor Fergus Caskey, Professor of Renal Medicine, University of Bristol and Consultant Nephrologist at North Bristol NHS Trust
Professor Yoav Ben-Shlomo, Clinical Epidemiologist, University of Bristol
Dr Pippa Bailey, Consultant Senior Lecturer in Renal Medicine, University of Bristol

The following researchers from NIHR ARC West have worked with the Kidney Disease HIT: